Dr. Anna Malashicheva

Anna Malashicheva is a PI at Almazov National Medical Research Centre; scientific interests cover developmental biology, cellular biology, translational medicine, cardiovascular disease pathogenesis.

Mentor for 3 PhD students and several Master students yearly;

Course of lectures on stem cells biology and development at Saint Petersburg State University and several teaching courses in translational medicine at Almazov National Medical Research Centre;

Coordinator of a collaborative research group between  Almazov National research centre and Oslo University, coordinator between National Almazov Medical Research Centre, St. Petersburg State University and Institute of Cytology, Russian Academy of Sciences

Author and co-author of about 40 publications in international peer-reviewed journals.

Most important recent publications: 

  1. Malashicheva A, Kostina A, Shishkova A, Ignatieva E, Irtyuga O, Semenova D., Golovkin A, Zhiduleva E, Uspenskiy V, Moiseeva O, Kostareva A. Osteogenic potential of adipose mesenchymal stem cells is not correlated with aortic valve calcification. Biol. Comm., 2018(3) :36-42
  2. Kostina A, Bjork H., Ignatieva E, Irtyuga O, Uspenskiy V, Semenova D., Maleki S., Tomilin A, Moiseeva O., Franco-Cereceda A, Faggian G, Kostareva A, Eriksson P, Malashicheva A. Notch, BMP and WNT/β-catenin network is impaired in endothelial cells of the patients with thoracic aortic aneurysm. Athrosclerosis Suppl, 2018, accepted. IF 3,2 Q1
  3. Björck HM, Du L, Pulignani S, Paloschi V, Lundströmer K, Kostina AS, Österholm C, Malashicheva A, Kostareva A, Evangelista A, Teixidó-Tura G, Maleki S, Franco-Cereceda A, Eriksson P . Altered DNA methylation indicates an oscillatory flow mediated epithelial-to-mesenchymal transition signature in ascending aorta of patients with bicuspid aortic valve. Mechanistic Interrogation of Bicuspid Aortic Valve associated Aortopathy (MIBAVA) Leducq Consortium. Sci Rep. 2018 Feb 9;8(1):2777. doi: 10.1038/s41598-018-20642-4. IF 4.8, Q1 Nature group
  4. Kostina A, Shishkova A, Ignatieva E, Irtyuga O, Bogdanova M, Levchuk K, Golovkin A, Zhiduleva E, Uspenskiy V, Moiseeva O, Faggian G, Vaage J, Kostareva A, Rutkovskiy A, Malashicheva A. Different Notch signaling in cells from calcified bicuspid and tricuspid aortic valves. J Mol Cell Cardiol. 2018 Jan;114:211-219. doi: 10.1016/j.yjmcc.2017.11.009. IF 5,68  Q1
  5. Lamin A/C mutation associated with lipodystrophy influences adipogenic differentiation of stem cells through interaction with Notch signaling. Perepelina K, Dmitrieva R, Ignatieva E, Borodkina A, Kostareva A, Malashicheva A. Biochem Cell Biol. 2018 Jun;96(3):342-348. doi: 10.1139/bcb-2017-0210. IF 1,7
  6. Khudiakov, A., Kostina, D., Zlotina, A., Yany, N., Sergushichev, A., Pervunina, T., Tomilin, A., Kostareva, A., Malashicheva, A., 2017. Generation of iPSC line from patient with arrhythmogenic right ventricular cardiomyopathy carrying mutations in PKP2 gene. Stem Cell Res. 24, 85–88. doi:10.1016/j.scr.2017.08.014
    IF 3,8 Q1
  7. Ignatieva E, Kostina D, Irtyuga O, Uspensky V, Golovkin A, Gavriliuk N, Moiseeva O, Kostareva A, Malashicheva A. Mechanisms of Smooth Muscle Cell Differentiation Are Distinctly Altered in Thoracic Aortic Aneurysms Associated with Bicuspid or Tricuspid Aortic Valves. Front Physiol. 2017 Jul 25;8:536
    IF 4,1 Q1
  8. Rutkovskiy A, Malashicheva A, Sullivan G, Bogdanova M, Kostareva A, Stensløkken KO, Fiane A, Vaage J. Valve Interstitial Cells: The Key to Understanding the Pathophysiology of Heart Valve Calcification. J Am Heart Assoc. 2017 Sep 14;6(9). pii: e006339. doi: 10.1161/JAHA.117.006339. IF 5,1 Q1
  9. Kostina D, Zverev D, Gordeev M, Ignatieva E, Voronkina I, Kostareva A, Malashicheva A. Aortic graft at coronary artery bypass surgery as a source of human aortic smooth muscle cells. Cell Transplant. 2017 Oct;26(10):1663-1668. doi: 10.1177/0963689717721226. IF 3,2 Q1
  10. Kostina AS, Uspensky VЕ, Irtyuga OB, Ignatieva EV, Freylikhman O, Gavriliuk ND, Moiseeva OM, Zhuk S, Tomilin A, Kostareva АА, Malashicheva AB. Notch-dependent EMT is attenuated in patients with aortic aneurysm and bicuspid aortic valve. Biochim Biophys Acta. 2016 Apr;1862(4):733-40
    IF 5,2 Q1