Dr. Wolf-Dieter Grimm

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Dr. Wolf-Dieter Grimm, PhD, MSc, Senior Professor of Periodontology, University of Witten/Herdecke, Periodontology, Department of Dental Medicine, Faculty of Health,

e-mail: prof_wolf.grimm@yahoo.de

 

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Dr. Wolf-Dieter Grimm, PhD, MSc, Professor of Stem Cell Technology, Chief Researcher, Stem Cell Lab, Institute of Regenerative Medicine, Stavropol State Medical University

 

Education and Training

Wolf-Dieter Grimm, clinical periodontist, graduated from dentistry, St. Petersburg State University in 1968. He worked for Technical University Dresden, for Academy of Postgraduate Programs in Dentistry Schwerin, and University of Witten, Faculty of Health, Germany 1991 to date. Since 1992, he became the Chairman of Department of Periodontology, Faculty of Dental Medicine, University of Witten and the director of Dental clinics 1993-97. From 1997-2005, he worked in USA as an Adjunct Professor in the Department of Periodontology, University of North Carolina at Chapel Hill.

As PI and Professor of Periodontology he has decades of experience with the diagnostic and treatment of periodontal diseases.

Prof. Grimm has developed methods for minimal-invasive periodontal surgery including surgical instruments for micro-surgical treatment of periodontitis.

He has developed advanced course for post-graduate training in Periodontal Medicine (Postgraduate Curriculum of Periodontology) provided for dentists specializing in Clinical Periodontics since 2003. Prof. Grimm is Specialist™ of Periodontology (German Society of Periodontology/European Federation of Periodontology).

Since 2006 he focused on Stem cells in Regenerative Medicine.

Since September 2014 up to August 2016 Prof. Grimm has worked as Distinguished Gottfried Herder Exchange Program Professor of Stomatology (Germany) at Stavropol State Medical University (Russian Federation). Since May 2016 Prof. Grimm is working as Chief Researcher, Professor, Stem Cell Lab, Institute of Regenerative Medicine, Stavropol State Medical University.

During his active research time as visiting research fellow at the Center for Oral and Systemic diseases (Director: Prof. Dr. St. Offenbacher) from 1997 up to 1998 and later on as Adjunct Professor of Periodontology (1998-2005) at the Department of Periodontology (Professor and Chair: Prof Dr. R. Williams) at the University of North Carolina at Chapel Hill (see also publication references), Prof. Grimm has developed rodent (rat and mice) animal models including animal treatment and experimental surgery (titanium chamber model); histological techniques (organ/tissue/cell isolation, fixation, processing for light/scanning electron microscopy, embedding, sectioning, specific/differential staining) and radioactive labeling in vivo/in vitro, autoradiography; for the investigation of periodontitis related to systemic diseases and for periodontal regeneration, now established in cooperation with the Anatomy and the Institute of Immunology, and the Animal facility Campus Witten of the Faculty of Health. In addition to the 2001 Colgate-Research Award, most awards to him were for the basic science in dentistry. Since 2006 he focused on Stem cells in Regenerative Medicine. In standardized animal model, he investigated stem cell-supported periodontal and alveolar bone regeneration in nude rat. In general, my current stem cell research is focused on adult (somatic) stem cells and the regulation of their fundamental biological properties including differentiation, proliferation, and migration. We are further interested in the impact of pro- and anti-inflammatory signals on mesenchymal stem cells (progenitor of bone, fat and cartilage tissue) and neural crest-derived cells (progenitor of e.g. pigment cells and bones within the head region).

Among others, my research team wants to address the following questions:

  • How do inflammation and infection influence stem cell-mediated regeneration of the bone tissues? Are pro- and anti-inflammatory signals beneficial or harmful to adult stem cells?
  • What is the ideal stem cell type for personalized regenerative medicine?
  • It is possible to increase the regenerative potential of autologous (belonging to the given patient), tissue-resident stem cells by manipulating the inflammatory balance?
  • Can such de-differentiation approach be used within Regenerative Medicine?
  • What are the best conditions and methods to cultivate stem cells (3D vs 2D culture, biomaterials)
  • What are the best techniques for vertical and horizontal augmentations of alveolar bone defects using bone substitutes as carrier material for human neural crest-derived cells

Most important publications due to stem cell and growth factor`s research

  1. Grimm, W.-D., P. Cichon, H. van der Hoeven, P. S. Langendijk, F. Smith, M. Worley, I. Schmitz, S. Offenbacher. The influence of Sulfate Reducing Bacteria (SRB) colonization of two different bioresorbable barrier membranes for guided tissue regeneration. A case-controlled microbiological and clinical study over 18 months. Int J Periodontics Restorative Dent 20: 2000, 93-99. IF: 1.702
  2. Langendijk-Genevaux, P.S., W.-D. Grimm, J.S. van der Hoeven. Sulfate-reducing bacteria in relation with other potential periodontal pathogens. J Clin Periodontol 28: 2001, 1151-1157. IF: 3.549
  3. Grimm, W.-D., W. H. Arnold, M. Dietrich, H. Morgner. Three-Dimensional Surface Pattern and Chemical Composition of Mucosal Titanium Implant Compartments. Mater Trans 43: 2002, 3036-3042. IF: 0.795
  4. Widera D, Grimm W-D, Moebius J, Piechaczek C, Gaßmann G, Wolff N, Thévenod F, Kaltschmidt C, Kaltschmidt B. Highly Efficient neural differentiation of human somatic stem cells, isolated via minimally-invasive periodontal surgery. Stem Cells Dev 2007; 16 (3):447-60. IF: 4.146
  5. Widera D, Grimm WD, Möbius JM, Dannan A, Becher S, Mikenberg I, Piechaczek C, Gassmann G, Kaltschmidt B: Human periodontium-derived neural stem cells: chance or risk? Regenerative Medicine 2007, 2:3-61. IF: 3.873
  6. Gassmann G, Schwenk B, Entschladen F, Grimm WD. Influence of enamel matrix derivative on primary CD4+ T-helper lymphocyte migration, CD25 activation, and apoptosis. J Periodontol. 2009; 80(9):1524-33, EpubSep 2009. IF: 2.192
  7. Király M, Porcsalmy B, Pataki A, Kádár K, Jelitai M, Molnár B, Hermann P, Gera I, Grimm WD, Ganss B, Zsembery A, Varga G. Simultaneous PKC and cAMP activation induces differentiation of human dental pulp stem cells into functionally active neurons. Neurochem Int. 2009 Sep;55(5):323-32. Epub Apr 5, 2009. IF: 3.541
  8. Arnold WH., S Becher, D Widera, M Jacob, HG Mannherz, Th Dittmar and WD Grimm. Morphological characterization of periodontium-derived human stem cells. Ann Anat 2010; 192:215–219, http://dx.doi.org/10.1016/j.aanat.2010.05.004. IF: 0.877
  9. Grimm WD, A Dannan, S Becher, G Gassmann, WH Arnold, G Varga, Th Dittmar. The Ability of Human Periodontium-derived Stem Cells to Regenerate Periodontal Tissues-A Preliminary in vivo Investigation. Int. J Periodont. Rest. Dentistry 30: 2011, Vol. 31, Nr. 6, e94-e101. IF: 1.702
  10. Keeve PL, Dittmar T, Gassmann G, Grimm WD, Niggemann B, Friedmann A. Characterization and analysis of migration patterns of dentospheres derived from periodontal tissue and the palate Characterization and analysis of migration patterns of dentospheres derived from periodontal tissue and the palate. J Periodontal Res. 2013 Jun;48(3):276-85. doi: 10.1111/jre.12005. Epub 2012 Oct 3. IF: 1.99
  11. Grimm, W.-D., Plöger, M., Schau, I., Vukovic, M.A., Sirak, S.V., Shchetinin E.V. Complex, three-dimensional reconstruction of critical size defects following delayed implant placement using stem cell-containing subepithelial connective tissue graft and allogenic human bone blocks for horizontal alveolar bone augmentation: A case report as proof of clinical study principles. Medical News of North Caucasus 2014 9 (2), 131-133. http://www.scopus.com/inward/record.url?eid=2-s2.0-84904707876&partnerID=40&md5=f08a32f4e104837af9ea73f3953a4023
  12. Grimm, W.D., Dannan, A., Giesenhagen, B., Schau, I., Varga, G., Vukovic, M.A., Sirak, S.V.

Translational research: Palatal-derived ecto-mesenchymal stem cells from human palate: A new hope for alveolar bone and cranio-facial bone reconstruction. Inter J Stem Cells 2014 7 (1), 23-29. doi: 10.15283/ijsc.2014.7.1.23 http://www.scopus.com/inward/record.url?eid=2-s2.0-84901672088&partnerID=40&md5=9a032758b961fbeaa8b34cd388aa63cd

  1. Grimm, W.-D., Plöger, M., Schau, I., Vukovic, M.A., Shchetinin, E.V., Akkalaev, A.B., Arutunov, A.V., Sirak, S.V. Prefabricated 3D allogenic bone block in conjunction with stem cell-containing subepithelial connective tissue graft for horizontal alveolar bone augmentation: A case report as proof of clinical study principles. Medical News of North Caucasus 2014 9 (2), pp. 175-178. http://www.scopus.com/inward/record.url?eid=2-s2.084904632350&partnerID=40&md5=57a4cfb02fbfd8bfb43d363f39240177
  2. Grimm WD, B. Giesenhagen, S. Hakki, I. Schau, S. Sirak, A. Sletov, G. Varga, M. A. Vukovic, D. Widera. Translational Research and Therapeutic Applications of Neural Crest-Derived Stem Cells in Regenerative Periodontology. Curr Oral Health Rep 2015 DOI 10.1007/s40496-015-0067-6
  3. Grimm WD, E.V. Shchetinin, D.V. Bobrishev, S.V. Sirak. Quantifying analysis of advanced glycosylation end products (ages) expression in periodontitis patients with diabetes type II. Medical News of North Caucasus 2015, vol. 10 Issue 2, 111-115 https://doi.org/10.14300/mnnc.2015.10042
  4. Grimm Wolf-Dieter; Tilman Fritsch; Bernd Giesenhagen; Sergey Sirak; Alexandr Sletov; Magomet Aybazov; S. Tebyakina; Evgeny Shchetinin; Alexander Vukovic; Ivan Koshel. Neural crest-related stem cells of oral origins in vitro and used in osteoporotic sheep model- to be investigated due to therapeutic effects in alveolar bone regeneration. Medical News of North Caucasus 2016, vol. 11 Issue 2, 192-196, DOI – http://dx.doi.org/10.14300/mnnc.2016.11034
  5. Grimm, W. D., S. V. Sirak, A. A. Adamchik, M. M. Aybazov, D. V. Bobryshev, N. N. Didenko, M. O. Didenko, T. Fritsch, B. Giesenhagen, I. V. Koshel, G. G. Petrosyan, E. V. Shchetinin, A. G. Sirak, A. A. Sletov, S. V. Tebyakina, and O. V. Vladimirova, “Osteoporotic Sheep mandibular model for comparative alveolar bone healing research. A proof of principle study”. Med. News North Caucasus, 2017, DOI – https://doi.org/10.14300/mnnc.2017.12091
  6. Zeuner Marie-Theres, Liam Turner, David Humphries, Sokratis Stergiadis, Taryn Morash, Ketan Patel, Wolf-Dieter Grimm, Darius Widera. Isolation and Characterisation of Adult Ovine Neural Crest-Derived Stem Cells from Palatal Tissue. Front. Bioeng. Biotechnol. 2018, https://doi.org/10.3389/fcell.2018.00039
  7. Sergey Sirak, Tilman Fritsch, Bernhard Giesenhagen, Evgeny Shchetinin, Alexander Sletov, Wolf Grimm. Osteogenic Potential of Porous Titanium. An Experimental Study in Sheep. Journal Nat Med Ass_2018_49_R1, in press
  8. Schau Ingmar, Mathias Plöger, K. Schaper, S. V. Sirak, M.V. Vukovic, Wolf-Dieter Grimm. Three-year-analysis of peri-implant bone level after allogenic bone-block augmentation. Journal of Indian Society of Periodontology 2018 jisp_351_16, in press

 

Honors, Grants and Awards

2001 Colgate-Research Award, basic research in Dentistry (Gold Medal)

2003 Colgate-Research Award, basic research in Dentistry (Bronze Medal)

2007 Dissertation – 1.Award („Nachweis und Quantifizierung von Parodontitis-assoziierten Sulfat reduzierenden Bakterien (SRB) mittels quantitativer PCR“), University Witten/Herdecke

2008 Dissertation – 1. Award „Enamel Matrix Derivative stimulates apoptosis of T cell-lymphocytes in vitro. University Witten/Herdecke, Faculty of Dental Medicine, awarded by Heraeus-Kulzer

 

Patent

PCT/EP2006/066221“A post-natal periodontal-derived neural stem cell”

Professional Activities and Memberships

Membership National and International Associations

since 2008-     Stem Cell Network North Rhine Westphalia, Germany

since 1998-     International Academy of Periodontology (IAP)

since 1998-     American Academy of Periodontology (AAP)

since 1991-     International Association of Dental Research (IADR)

since 1991-     Working Group Periodontology, International Association of Dental Research

since 1991-     Continental European Division (CED) of IADR

since 1968-     Deutsche Gesellschaft für Zahn-, Mund- und Kieferheilkunde (DGZMK)

since 1975-     Deutsche Gesellschaft für Parodontologie (DGP)

since 1991-     Arbeitsgemeinschaft für Grundlagenforschung (AfG)

since 1991-     Deutsche Gesellschaft für Zahnerhaltung (DGZ)

since 1992-     Vereinigung der Hochschullehrer für Zahn-, Mund- und Kieferheilkunde (VHZMK)

 

ad-hoc reviewer for

Journal of Periodontal Research <https://publons.com/author/edit/#profile-settings>